Analytical-numerical methods of calculations of energy and three-dimensional particle distributions in electromagnetic cascades

Analytical and numerical methods of calculation of the energy and three dimensional EPS characteristics are reported. The angular and lateral functions of electrons in EPS have been obtained by the Landau and small angle approximations A and B and compared with earlier data. A numerical method of solution of cascade equations for the EPS distribution function moments has been constructed. Considering the equilibrium rms angle as an example, errors appearing when approximating the elementary process cross sections by their asymptotic expressions are analyzed

Estimation of the total inelasticity coefficient in interaction of greater than or equal to 20 TeV hadrons with lead

Experimental data on the interaction mean free path of hadrons with energy E 20 TeV in lead obtained with multilayer X-ray emulsion chambers(XEC) are compared with results of simulation of nuclear-electromagnetic cascades in lead chamber. It is shown that, to explain experimental data, the value of the inelasticity coefficients, K .8 should be assumed

Sensitivity of depth of maximum and absorption depth of EAS to hadron production mechanism

Comparison of experimental data on depth of extensive air showers (EAS) development maximum in the atmosphere, T sub M and path of absorption, lambda, in the lower atmosphere of EAS with fixed particle number in the energy region eV with the results of calculation show that these parameters are sensitive mainly to the inelastic interaction cross section and scaling violation in the fragmentation and pionization region. The data are explained in a unified manner within the framework of a model in which scaling is violated slightly in the fragmentation region and strongly in the pionization region at primary cosmic rays composition close to the normal one and a permanent increase of inelastic interaction cross section. It is shown that, while interpreting the experimental data, disregard of two methodical points causes a systematic shift in T sub M: (1) shower selection system; and (2) EAS electron lateral distribution when performing the calculations on basis of which the transfer is made from the Cerenkov pulse FWHM to the depth of shower maximum, T sub M

Electromagnetic showers in a strong magnetic field

We present the results concerning the main shower characteristics in a strong magnetic field obtained through shower simulation. The processes of magnetic bremsstrahlung and pair production were taken into account for values of the parameter $\chi \gg 1$. We compare our simulation results with a recently developed cascade theory in a strong magnetic field.Comment: 11 pages, 9 eps figures, LaTex2e, Iopart.cls, Iopart12.clo, Iopams.st

Investigating knowledge management factors affecting Chinese ICT firms performance: An integrated KM framework

This is an Author's Accepted Manuscript of an article published in the Journal of Information Systems Management, 28(1), 19 - 29, 2011, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/10580530.2011.536107.This article sets out to investigate the critical factors of Knowledge Management (KM) which are considered to have an impact on the performance of Chinese information and communication technology (ICT) firms. This study confirms that the cultural environment of an enterprise is central to its success in the context of China. It shows that a collaborated, trusted, and learning environment within ICT firms will have a positive impact on their KM performance

Space-VLBI observations of OH maser OH34.26+0.15: low interstellar scattering

We report on the first space-VLBI observations of the OH34.26+0.15 maser in two main line OH transitions at 1665 and 1667 MHz. The observations involved the space radiotelescope on board the Japanese satellite HALCA and an array of ground radio telescopes. The map of the maser region and images of individual maser spots were produced with an angular resolution of 1 milliarcsec which is several times higher than the angular resolution available on the ground. The maser spots were only partly resolved and a lower limit to the brightness temperature 6x10^{12} K was obtained. The maser seems to be located in the direction of low interstellar scattering, an order of magnitude lower than the scattering of a nearby extragalactic source and pulsar.Comment: 8 pages, 2 tables, 9 figures, accepted for publication in MNRA

Ultra-High Energy Gamma Rays in Geomagnetic Field and Atmosphere

The nature and origin of ultra-high energy (UHE: reffering to > 10^19 eV) cosmic rays are great mysteries in modern astrophysics. The current theories for their explanation include the so-called "top-down" decay scenarios whose main signature is a large ratio of UHE gamma rays to protons. Important step in determining the primary composition at ultra-high energies is the study of air shower development. UHE gamma ray induced showers are affected by the Landau-Pomeranchuk-Migdal (LPM) effect and the geomagnetic cascading process. In this work extensive simulations have been carried out to study the characteristics of air showers from UHE gamma rays. At energies above several times 10^19 eV the shower is affected by geomagnetic cascading rather than by the LPM effect. The properties of the longitudinal development such as average depth of the shower maximum or its fluctuations depend strongly on both primary energy and incident direction. This feature may provide a possible evidence of the UHE gamma ray presence by fluorescence detectors.Comment: 27 pages, 12 figures, submitted to Phys.Rev.

СПОСОБ РАЗДЕЛЬНОГО ОПРЕДЕЛЕНИЯ СОПРОТИВЛЕНИЙ ОБРАЗЦА ВЫСОКООМНОГО ПОЛУПРОВОДНИКА И КОНТАКТОВ К ОБРАЗЦУ

The method of separate determination of two−pole sample volume resistance and contact resistance is suggested. The method described is applicable to high−ohmic semiconductor samples: semiinsulating gallium arsenide, detector cadmium−zinc tel- luride (CZT), etc. The method is based on near−contact region illumination by monochromatic radiation of variable intensity from light emitting diodes with quantum energy exceeding band gap width of investigated material. It is necessary to obtain sample photo−current dependence upon light emitting diode current and to find the straight−line part of this dependence. The extrapola- tion of this linear part to ordinate axis gives cut−off current value. As bias voltage is known, it is easy to calculate sample volume resistance value. Afterwards, using dark current value, it is pos- sible to determine total contact resistance. The method was approbated on n−type semiinsulating GaAs sample. Contact resistance value was shown to be approximately equal to sample volume resistance. It means that influence of contacts must be taken into account when electrophysical data is analyzed.Предложен метод раздельного определения сопротивлений образца−двухполюсника и контактов к нему, который применим к образцам высокоомных полупроводниковых материалов: полуизолирующего арсенида галлия, детекторного теллурида кадмия−цинка (КЦТ) и др. Метод основан на засветке приконтакных областей образца моно- хроматическим излучением регулируемой интенсивности от светодиодов с энергией кванта, превышающей ширину запрещенной зоны исследуемого материала. Экстраполяция прямолинейного участка зависимости фототока через образец от тока через светодиоды к оси ординат позволяет найти ток отсечки, после чего по из- вестным значениям тока отсечки и напряжения смещения вычисляют значение сопротивления объема об- разца. Далее, зная темновое значение тока через образец, можно вычислить суммарное сопротивление контактов образца−двухполюсника. Метод опробован на образце полуизолирующего арсенида галлия n−типа электропроводности. Линейность контактов проверена по вольт−амперным характеристикам. Показано, что сопротивление контактов близко к сопротивлению объема образца, что подтверждает необходимость учета влияния контактов при анализе данных электрофизических измерений

Metabolically stable bradykinin B2 receptor agonists enhance transvascular drug delivery into malignant brain tumors by increasing drug half-life

<p>Abstract</p> <p>Background</p> <p>The intravenous co-infusion of labradimil, a metabolically stable bradykinin B2 receptor agonist, has been shown to temporarily enhance the transvascular delivery of small chemotherapy drugs, such as carboplatin, across the blood-brain tumor barrier. It has been thought that the primary mechanism by which labradimil does so is by acting selectively on tumor microvasculature to increase the local transvascular flow rate across the blood-brain tumor barrier. This mechanism of action does not explain why, in the clinical setting, carboplatin dosing based on patient renal function over-estimates the carboplatin dose required for target carboplatin exposure. In this study we investigated the systemic actions of labradimil, as well as other bradykinin B2 receptor agonists with a range of metabolic stabilities, in context of the local actions of the respective B2 receptor agonists on the blood-brain tumor barrier of rodent malignant gliomas.</p> <p>Methods</p> <p>Using dynamic contrast-enhanced MRI, the pharmacokinetics of gadolinium-diethyltriaminepentaacetic acid (Gd-DTPA), a small MRI contrast agent, were imaged in rodents bearing orthotopic RG-2 malignant gliomas. Baseline blood and brain tumor tissue pharmacokinetics were imaged with the 1^stbolus of Gd-DTPA over the first hour, and then re-imaged with a 2^ndbolus of Gd-DTPA over the second hour, during which normal saline or a bradykinin B2 receptor agonist was infused intravenously for 15 minutes. Changes in mean arterial blood pressure were recorded. Imaging data was analyzed using both qualitative and quantitative methods.</p> <p>Results</p> <p>The decrease in systemic blood pressure correlated with the known metabolic stability of the bradykinin B2 receptor agonist infused. Metabolically stable bradykinin B2 agonists, methionine-lysine-bradykinin and labradimil, had differential effects on the transvascular flow rate of Gd-DTPA across the blood-brain tumor barrier. Both methionine-lysine-bradykinin and labradimil increased the blood half-life of Gd-DTPA sufficiently enough to increase significantly the tumor tissue Gd-DTPA area under the time-concentration curve.</p> <p>Conclusion</p> <p>Metabolically stable bradykinin B2 receptor agonists, methionine-lysine-bradykinin and labradimil, enhance the transvascular delivery of small chemotherapy drugs across the BBTB of malignant gliomas by increasing the blood half-life of the co-infused drug. The selectivity of the increase in drug delivery into the malignant glioma tissue, but not into normal brain tissue or skeletal muscle tissue, is due to the inherent porous nature of the BBTB of malignant glioma microvasculature.</p